Boston, MA—Dustin Pedroia tied the game in the ninth with a sacrifice fly and Josh Reddick won it for Boston in the 10th with an RBI single.
With men on first and second and one out, Reddick laced Phil Hughes' offering down the left-field line to give the Red Sox a 3-2 win over the New York Yankees.
"Got a first-pitch curveball over the plate and didn't really miss it," Reddick said.
Marco Scutaro went 4-for-4 with an RBI and run scored for Boston, which sits a game ahead of the Yankees in the AL Eaststandings.
Boston starter Josh Beckett gave up one run on six hits over six innings.
Daniel Bard (2-5) tossed a perfect 10th to pick up the win.
Brett Gardner and Eduardo Nunez hit solo homers for the Yankees, who have lost 10 of 12 against Boston this season. With only six games left against the Red Sox this year, the Yankees have lost the season set against their rival for the first time since 2004.